| 2022-04-09 18:00:00April 9, 2022 | Capital Pioneers  | 14 - 6 |  Oregon Cougars | Salem, OR |
| 2022-04-09 18:00:00April 9, 2022 | Detroit Venom  | 8 - 27 |  Pittsburgh Passion | Detroit, MI |
| 2022-04-09 18:00:00April 9, 2022 | Seattle Spartans  | 0 - 20 |  Portland Fighting Shockwave | Seattle, WA |
| 2022-04-09 18:00:00April 9, 2022 | Carolina Phoenix  | 57 - 33 |  Richmond Black Widows | Greensboro, NC |
| 2022-04-09 18:00:00April 9, 2022 | Sun City Stealth  | 23 - 36 |  Rocky Mountain Thunderkatz | El Paso, TX |
| 2022-04-09 18:00:00April 9, 2022 | Columbus Chaos  | 6 - 14 |  St. Louis Slam | Columbus, OH |
| 2022-04-09 18:00:00April 9, 2022 | East Tennessee Valkyrie  | 8 - 0 |  Virginia Lady Firehawks | Johnson City, TN |
| 2022-04-09 18:00:00April 9, 2022 | Gulf Coast Monarchy  | 6 - 32 |  Zydeco Spice | Gulfport, MS |
| 2022-04-09 18:00:00April 9, 2022 | Austin Outlaws  | 6 - 40 |  Arlington Impact | Austin, TX |
| 2022-04-09 18:00:00April 9, 2022 | Derby City Dynamite  | 8 - 30 |  Capital City Savages | Louisville, KY |
| 2022-04-09 18:00:00April 9, 2022 | Arizona Outkast  | 52 - 18 |  Cruces Regulators | Phoenix, AZ |
| 2022-04-09 18:00:00April 9, 2022 | D.C. Divas  | 67 - 6 |  Baltimore Nighthawks | Washington, DC |
| 2022-04-09 18:00:00April 9, 2022 | Columbus Vanguards  | 0 - 44 |  Grand Rapids Tidal Waves | Columbus, IN |
| 2022-04-09 18:00:00April 9, 2022 | Dallas Elite Mustangs  | 8 - 42 |  Houston Energy | Dallas, TX |
| 2022-04-09 18:00:00April 9, 2022 | Minnesota Vixen  | 55 - 0 |  Iowa Phoenix | Minneapolis, MN |
| 2022-04-09 18:00:00April 9, 2022 | North Carolina Fierce  | 12 - 30 |  Jacksonville Dixie Blues | Fayetteville, NC |
| 2022-04-09 18:00:00April 9, 2022 | California Crush  | 12 - 7 |  Kern County Crusaders | Lancaster, CA |
| 2022-04-09 18:00:00April 9, 2022 | Nebraska Valkyries  | 7 - 38 |  Mile High Blaze | Omaha, NE |
| 2022-04-09 18:00:00April 9, 2022 | Harrisburg Havoc  | 6 - 27 |  New York Knockout | Harrisburg, PA |
| 2022-04-09 18:00:00April 9, 2022 | Maine Mayhem  | 0 - 18 |  New York Wolves | Portland, ME |
| 2022-04-09 18:00:00April 9, 2022 | Connecticut Hawks  | 14 - 0 |  Northern Connecticut Nightmare | Waterbury, CT |
| 2022-04-09 18:00:00April 9, 2022 | Houston Power  | 2 - 12 |  OKC Lady Force | Houston, TX |
| 2022-04-16 18:00:00April 16, 2022 | Sun City Stealth | 0 - 36 | Arizona Outkast | El Paso, TX |
| 2022-04-16 18:00:00April 16, 2022 | Houston Energy | 30 - 34 | Arlington Impact | Houston, TX |
| 2022-04-16 18:00:00April 16, 2022 | Tri State Warriors  | 0 - 13 | Baltimore Nighthawks | New Brunswick, NJ |
| 2022-04-16 18:00:00April 16, 2022 | D.C. Divas | 28 - 69 |  Boston Renegades | Washington, DC |
| 2022-04-16 18:00:00April 16, 2022 | California Crush | 0 - 41 |  Cali War | Lancaster, CA |
| 2022-04-16 18:00:00April 16, 2022 | Music City Mizfits  | 0 - 14 | Carolina Phoenix | Nashville, TN |
| 2022-04-16 18:00:00April 16, 2022 | East Tennessee Valkyrie | 56 - 0 |  Cincinnati Sizzle | Johnson City, TN |
| 2022-04-16 18:00:00April 16, 2022 | Connecticut Hawks | 0 - 19 | Harrisburg Havoc | Waterbury, CT |
| 2022-04-16 18:00:00April 16, 2022 | Gulf Coast Monarchy | 6 - 14 | Houston Power | Gulfport, MS |
| 2022-04-16 18:00:00April 16, 2022 | Tampa Bay Inferno  | 76 - 0 | Jacksonville Dixie Blues | Tampa Bay, FL |
| 2022-04-16 18:00:00April 16, 2022 | New York Knockout | 21 - 6 | Maine Mayhem | Schenectady, NY |
| 2022-04-16 18:00:00April 16, 2022 | Iowa Phoenix | 14 - 33 | Nebraska Valkyries | Des Moines, IA |
| 2022-04-16 18:00:00April 16, 2022 | Mile High Blaze | 8 - 22 |  Nevada Storm | Denver, CO |
| 2022-04-16 18:00:00April 16, 2022 | Virginia Lady Firehawks | 42 - 7 | Richmond Black Widows | Hampton, VA |
| 2022-04-16 18:00:00April 16, 2022 | Minnesota Vixen | 41 - 6 | St. Louis Slam | Minneapolis, MN |
| 2022-04-16 18:00:00April 16, 2022 | Zydeco Spice | 42 - 13 |  Tulsa Threat | Lafeyette, LA |
| 2022-04-16 18:00:00April 16, 2022 | Orlando Anarchy  | 52 - 0 |  Daytona Waverunners | Orlando, FL |
| 2022-04-16 18:00:00April 16, 2022 | New York Wolves | 46 - 0 |  Northeast Ruckus | Utica, NY |
| 2022-04-23 18:00:00April 23, 2022 | Tampa Bay Inferno | 0 - 47 | Boston Renegades | Tampa Bay, FL |
| 2022-04-23 18:00:00April 23, 2022 | Arizona Outkast | 42 - 6 | California Crush | Phoenix, AZ |
| 2022-04-23 18:00:00April 23, 2022 | Virginia Lady Firehawks | 30 - 0 |  South Carolina Dames | Hampton, VA |
| 2022-04-23 18:00:00April 23, 2022 | Maine Mayhem | 26 - 0 | Connecticut Hawks | Portland, ME |
| 2022-04-23 18:00:00April 23, 2022 | Columbus Chaos | 22 - 24 | Derby City Dynamite | Columbus, OH |
| 2022-04-23 18:00:00April 23, 2022 | Capital City Savages | 12 - 21 | Detroit Venom | Flint, MI |
| 2022-04-23 18:00:00April 23, 2022 | Richmond Black Widows | 18 - 42 | East Tennessee Valkyrie | Richmond, VA |
| 2022-04-23 18:00:00April 23, 2022 | Dallas Elite Mustangs | 39 - 0 | Gulf Coast Monarchy | Dallas, TX |
| 2022-04-23 18:00:00April 23, 2022 | Austin Outlaws | 6 - 38 | Houston Energy | Austin, TX |
| 2022-04-23 18:00:00April 23, 2022 | Tulsa Threat | 0 - 22 | Iowa Phoenix | Tulsa, OK |
| 2022-04-23 18:00:00April 23, 2022 | Grand Rapids Tidal Waves | 52 - 6 |  Midwest Mountain Lions | Grand Rapids, MI |
| 2022-04-23 18:00:00April 23, 2022 | Rocky Mountain Thunderkatz | 0 - 22 | Mile High Blaze | Colorado Springs, CO |
| 2022-04-23 18:00:00April 23, 2022 | Columbus Vanguards | 0 - 42 | Music City Mizfits | Columbus, IN |
| 2022-04-23 18:00:00April 23, 2022 | OKC Lady Force | 12 - 5 | Nebraska Valkyries | Oklahoma City, OK |
| 2022-04-23 18:00:00April 23, 2022 | Jacksonville Dixie Blues | 14 - 18 | Orlando Anarchy | Jacksonville, FL |
| 2022-04-23 18:00:00April 23, 2022 | Oregon Cougars | 0 - 7 | Portland Fighting Shockwave | Eugene, OR |
| 2022-04-23 18:00:00April 23, 2022 | Northern Connecticut Nightmare | 6 - 40 | New York Knockout | Windsor, CT |
| 2022-04-23 18:00:00April 23, 2022 | Capital Pioneers | 20 - 8 | Seattle Spartans | Salem, OR |
| 2022-04-23 18:00:00April 23, 2022 | Cruces Regulators | 34 - 28 | Sun City Stealth | Las Cruces, NM |
| 2022-04-23 18:00:00April 23, 2022 | New York Wolves | 24 - 0 | Tri State Warriors | New York, NY |
| 2022-04-23 18:00:00April 23, 2022 | Sioux Falls Snow Leopards  | 2 - 0 |  Minnesota Minx | Sioux Falls, SD |
| 2022-04-23 18:00:00April 23, 2022 | Houston Power | 28 - 8 | Zydeco Spice | Houston, TX |
| 2022-04-30 18:00:00April 30, 2022 | Cali War | 55 - 0 | Arizona Outkast | Los Angeles, CA |
| 2022-04-30 18:00:00April 30, 2022 | Tulsa Threat | 0 - 26 | Austin Outlaws | Tulsa, OK |
| 2022-04-30 18:00:00April 30, 2022 | Portland Fighting Shockwave | 7 - 46 | Capital Pioneers | Portland, OR |
| 2022-04-30 18:00:00April 30, 2022 | Richmond Black Widows | 19 - 0 | South Carolina Dames | Richmond, VA |
| 2022-04-30 18:00:00April 30, 2022 | Capital City Savages | 67 - 0 | Columbus Vanguards | Flint, MI |
| 2022-04-30 18:00:00April 30, 2022 | Baltimore Nighthawks | 6 - 42 | D.C. Divas | Baltimore, MD |
| 2022-04-30 18:00:00April 30, 2022 | Arlington Impact | 34 - 7 | Dallas Elite Mustangs | Arlington, TX |
| 2022-04-30 18:00:00April 30, 2022 | St. Louis Slam | 38 - 6 | Derby City Dynamite | St. Louis, MO |
| 2022-04-30 18:00:00April 30, 2022 | Boston Renegades | 49 - 0 | Detroit Venom | Boston, MA |
| 2022-04-30 18:00:00April 30, 2022 | Virginia Lady Firehawks | 12 - 6 | East Tennessee Valkyrie | Hampton, VA |
| 2022-04-30 18:00:00April 30, 2022 | Iowa Phoenix | 32 - 6 | Houston Power | Des Moines, IA |
| 2022-04-30 18:00:00April 30, 2022 | Gulf Coast Monarchy | 20 - 0 | Jacksonville Dixie Blues | Gulfport, MS |
| 2022-04-30 18:00:00April 30, 2022 | Harrisburg Havoc | 12 - 40 | Maine Mayhem | Harrisburg, PA |
| 2022-04-30 18:00:00April 30, 2022 | Tampa Bay Inferno | 42 - 20 | Orlando Anarchy | Tampa Bay, FL |
| 2022-04-30 18:00:00April 30, 2022 | Houston Energy | 14 - 16 | Mile High Blaze | Houston, TX |
| 2022-04-30 18:00:00April 30, 2022 | Nevada Storm | 28 - 26 | Minnesota Vixen | Reno, NV |
| 2022-04-30 18:00:00April 30, 2022 | Connecticut Hawks | 7 - 67 | New York Wolves | Waterbury, CT |
| 2022-04-30 18:00:00April 30, 2022 | New York Knockout | 40 - 0 | Northeast Ruckus | Schenectady, NY |
| 2022-04-30 18:00:00April 30, 2022 | Rocky Mountain Thunderkatz | 0 - 38 | OKC Lady Force | Colorado Springs, CO |
| 2022-04-30 18:00:00April 30, 2022 | Carolina Phoenix | 63 - 0 | North Carolina Fierce | Greensboro, NC |
| 2022-04-30 18:00:00April 30, 2022 | Oregon Cougars | 8 - 6 | Seattle Spartans | Eugene, OR |
| 2022-04-30 18:00:00April 30, 2022 | Pittsburgh Passion | 35 - 0 | Tri State Warriors | Pittsburgh, PA |
| 2022-05-07 18:00:00May 7, 2022 | Orlando Anarchy | 48 - 0 | North Carolina Fierce | Orlando, FL |
| 2022-05-07 18:00:00May 7, 2022 | Minnesota Vixen | 42 - 26 | Arlington Impact | Minneapolis, MN |
| 2022-05-07 18:00:00May 7, 2022 | Houston Power | 12 - 16 | Austin Outlaws | Houston, TX |
| 2022-05-07 18:00:00May 7, 2022 | New York Wolves | 14 - 13 | Baltimore Nighthawks | New York, NY |
| 2022-05-07 18:00:00May 7, 2022 | Cincinnati Sizzle | 0 - 50 | Capital City Savages | Cincinnati, OH |
| 2022-05-07 18:00:00May 7, 2022 | Detroit Venom | 21 - 0 | Columbus Chaos | Detroit, MI |
| 2022-05-07 18:00:00May 7, 2022 | Grand Rapids Tidal Waves | 71 - 0 | Columbus Vanguards | Grand Rapids, MI |
| 2022-05-07 18:00:00May 7, 2022 | Rocky Mountain Thunderkatz | 28 - 32 | Cruces Regulators | Colorado Springs, CO |
| 2022-05-07 18:00:00May 7, 2022 | OKC Lady Force | 27 - 7 | Dallas Elite Mustangs | Oklahoma City, OK |
| 2022-05-07 18:00:00May 7, 2022 | Zydeco Spice | 62 - 14 | Gulf Coast Monarchy | Lafeyette, LA |
| 2022-05-07 18:00:00May 7, 2022 | Sioux Falls Snow Leopards | 28 - 0 | Midwest Mountain Lions | Sioux Falls, SD |
| 2022-05-07 18:00:00May 7, 2022 | Carolina Phoenix | 25 - 26 | Music City Mizfits | Greensboro, NC |
| 2022-05-07 18:00:00May 7, 2022 | Tulsa Threat | 12 - 14 | Nebraska Valkyries | Tulsa, OK |
| 2022-05-07 18:00:00May 7, 2022 | Cali War | 54 - 52 | Nevada Storm | Los Angeles, CA |
| 2022-05-07 18:00:00May 7, 2022 | Boston Renegades | 46 - 8 | Pittsburgh Passion | Boston, MA |
| 2022-05-07 18:00:00May 7, 2022 | Mile High Blaze | 65 - 0 | Sun City Stealth | Denver, CO |
| 2022-05-07 18:00:00May 7, 2022 | D.C. Divas | 0 - 21 | Tampa Bay Inferno | Washington, DC |
| 2022-05-07 18:00:00May 7, 2022 | California Crush | 18 - 12 | Oregon Cougars | Lancaster, CA |
| 2022-05-07 18:00:00May 7, 2022 | Portland Fighting Shockwave | 22 - 33 | Seattle Spartans | Portland, OR |
| 2022-05-14 18:00:00May 14, 2022 | St. Louis Slam | 21 - 49 | Boston Renegades | St. Louis, MO |
| 2022-05-14 18:00:00May 14, 2022 | Arlington Impact | 56 - 18 | Cali War | Arlington, TX |
| 2022-05-14 18:00:00May 14, 2022 | Grand Rapids Tidal Waves | 28 - 21 | Capital City Savages | Grand Rapids, MI |
| 2022-05-14 18:00:00May 14, 2022 | East Tennessee Valkyrie | 6 - 36 | Carolina Phoenix | Johnson City, TN |
| 2022-05-14 18:00:00May 14, 2022 | Northeast Ruckus | 20 - 13 | Connecticut Hawks | Raymond, NH |
| 2022-05-14 18:00:00May 14, 2022 | Detroit Venom | 35 - 14 | Derby City Dynamite | Detroit, MI |
| 2022-05-14 18:00:00May 14, 2022 | Richmond Black Widows | 16 - 39 | Harrisburg Havoc | Richmond, VA |
| 2022-05-14 18:00:00May 14, 2022 | Zydeco Spice | 8 - 54 | Houston Energy | Lafeyette, LA |
| 2022-05-14 18:00:00May 14, 2022 | Daytona Waverunners | 0 - 40 | Tampa Bay Inferno | Daytona, FL |
| 2022-05-14 18:00:00May 14, 2022 | Cincinnati Sizzle | 6 - 65 | Music City Mizfits | Cincinnati, OH |
| 2022-05-14 18:00:00May 14, 2022 | Portland Fighting Shockwave | 6 - 63 | Nevada Storm | Portland, OR |
| 2022-05-14 18:00:00May 14, 2022 | Maine Mayhem | 10 - 14 | New York Knockout | Portland, ME |
| 2022-05-14 18:00:00May 14, 2022 | Seattle Spartans | 8 - 14 | Oregon Cougars | Seattle, WA |
| 2022-05-14 18:00:00May 14, 2022 | Columbus Chaos | 6 - 35 | Pittsburgh Passion | Columbus, OH |
| 2022-05-14 18:00:00May 14, 2022 | Arizona Outkast | 35 - 8 | Sun City Stealth | Phoenix, AZ |
| 2022-05-14 18:00:00May 14, 2022 | Baltimore Nighthawks | 45 - 0 | Tri State Warriors | Baltimore, MD |
| 2022-05-14 18:00:00May 14, 2022 | Iowa Phoenix | 28 - 12 | Tulsa Threat | Des Moines, IA |
| 2022-05-14 18:00:00May 14, 2022 | Sioux Falls Snow Leopards | 12 - 14 | Minnesota Minx | Sioux Falls, SD |
| 2022-05-14 18:00:00May 14, 2022 | Cruces Regulators | 12 - 27 | OKC Lady Force | Las Cruces, NM |
| 2022-05-21 06:00:02May 21, 2022 | Music City Mizfits | 14 - 12 | East Tennessee Valkyrie | Nashville, TN |
| 2022-05-21 18:00:00May 21, 2022 | North Carolina Fierce | 6 - 40 | Daytona Waverunners | Fayetteville, NC |
| 2022-05-21 18:00:00May 21, 2022 | Nevada Storm | 12 - 20 | Cali War | Reno, NV |
| 2022-05-21 18:00:00May 21, 2022 | Seattle Spartans | 14 - 22 | Capital Pioneers | Seattle, WA |
| 2022-05-21 18:00:00May 21, 2022 | Columbus Vanguards | 8 - 20 | Cincinnati Sizzle | Columbus, IN |
| 2022-05-21 18:00:00May 21, 2022 | Derby City Dynamite | 16 - 14 | Columbus Chaos | Louisville, KY |
| 2022-05-21 18:00:00May 21, 2022 | New York Knockout | 55 - 6 | Connecticut Hawks | Schenectady, NY |
| 2022-05-21 18:00:00May 21, 2022 | Sun City Stealth | 20 - 48 | Cruces Regulators | El Paso, TX |
| 2022-05-21 18:00:00May 21, 2022 | Boston Renegades | 60 - 28 | D.C. Divas | Boston, MA |
| 2022-05-21 18:00:00May 21, 2022 | Houston Energy | 42 - 13 | Dallas Elite Mustangs | Houston, TX |
| 2022-05-21 18:00:00May 21, 2022 | Pittsburgh Passion | 19 - 28 | Detroit Venom | Pittsburgh, PA |
| 2022-05-21 18:00:00May 21, 2022 | Midwest Mountain Lions | 0 - 49 | Grand Rapids Tidal Waves | Milwaukee, WI |
| 2022-05-21 18:00:00May 21, 2022 | Jacksonville Dixie Blues | 26 - 0 | Gulf Coast Monarchy | Jacksonville, FL |
| 2022-05-21 18:00:00May 21, 2022 | Nebraska Valkyries | 21 - 6 | Iowa Phoenix | Omaha, NE |
| 2022-05-21 18:00:00May 21, 2022 | St. Louis Slam | 20 - 18 | Minnesota Vixen | St. Louis, MO |
| 2022-05-21 18:00:00May 21, 2022 | Tri State Warriors | 6 - 41 | New York Wolves | New Brunswick, NJ |
| 2022-05-21 18:00:00May 21, 2022 | Harrisburg Havoc | 0 - 59 | Virginia Lady Firehawks | Harrisburg, PA |
| 2022-05-21 18:00:00May 21, 2022 | Austin Outlaws | 26 - 12 | Zydeco Spice | Austin, TX |
| 2022-05-21 18:00:00May 21, 2022 | Northern Connecticut Nightmare | 0 - 50 | Maine Mayhem | Windsor, CT |
| 2022-05-28 18:00:00May 28, 2022 | Northeast Ruckus | - | Northern Connecticut Nightmare | Raymond, NH |
| 2022-05-28 18:00:00May 28, 2022 | Oregon Cougars | - | California Crush | Eugene, OR |
| 2022-05-28 18:00:00May 28, 2022 | Capital Pioneers | - | Portland Fighting Shockwave | Salem, OR |
| 2022-05-28 18:00:00May 28, 2022 | Dallas Elite Mustangs | - | Austin Outlaws | Dallas, TX |
| 2022-05-28 18:00:00May 28, 2022 | Baltimore Nighthawks | - | Columbus Chaos | Baltimore, MD |
| 2022-05-28 18:00:00May 28, 2022 | Music City Mizfits | - | Columbus Vanguards | Louisville, KY |
| 2022-05-28 18:00:00May 28, 2022 | Pittsburgh Passion | - | D.C. Divas | Pittsburgh, PA |
| 2022-05-28 18:00:00May 28, 2022 | Capital City Savages | - | Grand Rapids Tidal Waves | Flint, MI |
| 2022-05-28 18:00:00May 28, 2022 | Tri State Warriors | - | Harrisburg Havoc | New Brunswick, NJ |
| 2022-05-28 18:00:00May 28, 2022 | Nebraska Valkyries | - | Minnesota Vixen | Omaha, NE |
| 2022-05-28 18:00:00May 28, 2022 | Daytona Waverunners | - | Orlando Anarchy | Daytona, FL |
| 2022-05-28 18:00:00May 28, 2022 | Cruces Regulators | - | Rocky Mountain Thunderkatz | Las Cruces, NM |
| 2022-05-28 18:00:00May 28, 2022 | Midwest Mountain Lions | - | Sioux Falls Snow Leopards | Milwaukee, WI |
| 2022-05-28 18:00:00May 28, 2022 | Derby City Dynamite | - | St. Louis Slam | Louisville, KY |
| 2022-05-28 18:00:00May 28, 2022 | OKC Lady Force | - | Tulsa Threat | Oklahoma City, OK |
| 2022-05-28 18:00:00May 28, 2022 | Jacksonville Dixie Blues | - | Tampa Bay Inferno | Jacksonville, FL |
| 2022-07-09 19:00:44July 9, 2022 | | - | | Tom Benson Hall of Fame Stadium |
